Interventional Cardiology and Angiology

Local drug delivery (stent coating)

• Hypothesis
  Based on the forementioned facts, Ang II blockade might be a usefull approach to prevent neointimal formation after balloon angioplasty.
• Basic problem
  Until now, all pharmacological approaches to prevent restenosis have failed to demonstrate sufficiant efficacy. Sufficiant local drug concentration may be a crucial point.
• Local drug delivery systems
  might be a promising way, but only coated stents are suitable enough to realize local drug release.