Clinical Research Group Cardiomyopathy

Selected publications 1998 - 2003

• Grzeskowiak R, Witt H, Drungowski M, Thermann R, Hennig S, Perrot A, Osterziel KJ, Klingbiel D, Scheid S, Spang R, Lehrach H, Ruiz P. Expression profiling of human idiopathic dilated cardiomyopathy. Cardiovascular Res 2003; 59: 400-411.

• Geier C, Perrot A, �zcelik C, Binner P, Counsell D, Hoffmann K, Pilz B, Martiniak Y, Gehmlich K, van der Ven PFM, F�rst DO, Vornwald A, von Hodenberg E, N�rnberg P, Scheffold T, Dietz R, Osterziel KJ. Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy. Circulation. 2003;107: 1390-1395.

• Bunse M, Bit-Avragim N, Riefflin A, Perrot A, Schmidt O, Kreuz FR, Dietz R, Jung WI, Osterziel KJ. Cardiac energetics correlates to myocardial hypertrophy in Friedreich's Ataxia. Ann Neurol 2003; 53: 121-123.

• Osterziel KJ, Perrot A. Molecular basis of heart failure and dilated cardiomyopathy. Herz 2002; 27(8): 816-818.

• Perrot A, Osterziel KJ, Beck M, Dietz R, Kampmann C. Fabry disease: focus on cardiac manifestations and molecular mechanisms. Herz  2002; 27: 699-702.

• Ritter O, Hack S, Schuh K, Rothlein N, Perrot A, Osterziel KJ, Schulte HD, Neyses L. Calcineurin in human heart hypertrophy. Circulation  2002;105:2265-9.

• Voss A, Baier V, Schumann A, Hasart A, Reinsperger F, Schirdewan A, Osterziel KJ, Leder U. Postextrasystolic regulation patterns of blood pressure and heart rate in patients with idiopathic dilated cardiomyopathy. J Physiol 2002;538:271-8.

• Malberg H, Wessel N, Hasart A, Osterziel KJ, Voss A. Advanced analysis of spontaneous baroreflex sensitivity, blood pressure and heart rate variability in patients with dilated cardiomyopathy. Clin Sci (Lond) 2002;102:465-73.

• Kampmann C, Wiethoff CM, Perrot A, Beck M, Dietz R, Osterziel KJ. The heart in Anderson Fabry disease. Z Kardiol  2002;91:786-95.

• Osterziel KJ, Bit-Avragim N, Bunse M. Cardiac hypertrophy in Friedreich's ataxia. Cardiovasc Res 2002;54:694.

• Kabaeva ZT, Perrot A, Wolter B, Dietz R, Cardim N, Correia JM, Schulte HD, Aldashev AA, Mirrakhimov MM, Osterziel KJ. Systematic analysis of the regulatory and essential myosin light chain genes: genetic variants and mutations in hypertrophic cardiomyopathy. Eur J Hum Genet 2002;10:741-8.

• Cardim N, Perrot A, Ferreira T, Pereira A, Osterziel KJ, Reis RP, Correia JF. Usefulness of Doppler myocardial imaging for identification of mutation carriers of familial hypertrophic cardiomyopathy. Am J Cardiol 2002;90:128-32.

• Strohm O, Schulz-Menger J, Pilz B, Osterziel KJ, Dietz R, Friedrich MG. Measurement of left ventricular dimensions and function in patients with dilated cardiomyopathy. J Magn Reson Imaging 2001;13:367-371.

• Perrot A, Ranke MB, Dietz R, Osterziel KJ. Growth hormone treatment in dilated cardiomyopathy. J Card Surg 2001;16:127-31.

• Hoffmann B, Schmidt-Traub H, Perrot A, Osterziel KJ, GeBner R. First mutation in cardiac troponin C, L29Q, in a patient with hypertrophic cardiomyopathy. Hum Mutat 2001;17:524.

• Herrmann S, Schmidt-Petersen K, Pfeifer J, Perrot A, Bit-Avragim N, Eichhorn C, Dietz R, Kreutz R, Paul M, Osterziel KJ. A polymorphism in the endothelin-A receptor gene predicts survival in patients with idiopathic dilated cardiomyopathy. Eur Heart J 2001;22:1948-53.

• Bit-Avragim N, Perrot A, Sch�ls L, Hardt C, Kreuz F, Z�hlke C, Bubel S, Laccone F, Vogel H-P, Dietz R, Osterziel KJ. The GAA repeat expansion in intron 1 of the frataxin gene is related to the severity of cardiac manifestations in patients with Friedreich*s ataxia. Journal of Molecular Medicine 2001;J Mol Med:626-632.

• Anker SD, Volterrani M, Pflaum CD, Strasburger CJ, Osterziel KJ, Doehner W, Ranke MB, Poole-Wilson PA, Giustina A, Dietz R, Coats AJ. Acquired growth hormone resistance in patients with chronic heart failure: implications for therapy with growth hormone. J Am Coll Cardiol 2001;38:443-52.

• Wendel B, Reinhard R, Wachtendorf U, Zacharzowsky UB, Osterziel KJ, Schulte HD, Haase H, Hoehe MR, Morano I. The human beta-myosin heavy chain gene: Sequence diversity and functional characteristics of the protein. J.Cell Biochem. 2000;79:566-575.

• Strohm O, Schulz-Menger J, Philipp S, Osterziel KJ, Schubel B, Schneider W, Dietz R, Friedrich M. Biatrial Cardiac Myxoma. Journal of Cardiovascular Magnetic Resonance 2000;2:119-121.

• Osterziel KJ, Dietz R, Ranke MB. Increased Mortality Associated with Growth Hormone Treatment in Critically Ill Adults. New England Journal of Medicine 2000;342:134.

• Osterziel KJ, Ranke MB, Strohm O, Dietz R. The somatotrophic system in patients with dilated cardiomyopathy:  Relation of insulin-like growth factor-1 and its alterations during growth hormone therapy to cardiac function. Clinical Endocrinolgy 2000;53:61-68.

• Osterziel KJ, Blum WF, Strohm O, Dietz R. The severity of chronic heart failure due to coronary artery disease determines the effect of growth hormone therapy. Journal of Clinical Endocrinology and Metabolism 2000;85:1533-1539.

• Osterziel KJ, Bode-B�ger SM, Strohm O, Ellmer AE, Bit-Avragim N, H�nlein D, Ranke MB, Dietz R, B�ger RH. Role of nitric oxide in the cardiovascular effect of recombinant human growth hormone in patients with dilated cardiomyopathy. Cardiovascular Research 2000;45:447-453.

• Peukert S, Fu MLX, Eftekhari P, Poepping I, Voss A, Thalhammer.Ch., Hempel A, Menz M, Dietz R, Osterziel KJ. Correlation of serum autoantibodies with clinical manifestation in patients with hypertrophic cardiomyopathy. Autoimmunology 1999;29:291-297.

• Malberg H, Wessel N, Schirdewan A, Osterziel KJ, Voss A. Duale Sequenzmethode zur Analyse der spontanen Baroreflexsensitivit�t bei Patienten mit dilatativer Kardiomyopathie. Zeitschrift f�r Kardiologie 1999;88:331-337.

• Jung M, Poepping I, Perrot A, Ellmer AE, Wienker TF, Dietz R, Reis A, Osterziel KJ. Investigation of a family with autosomal dominant dilated cardiomyopathy defines a novel locus on chromosome 2q14-q22. Am J Hum Genet 1999;65:1068-77.

• Gerull B, Osterziel KJ, Dietz R, Thierfelder L. A rapid protocol for cardiac troponin T gene mutation detection in familial hypertrophic cardiomyopathy. Human Mutation 1998;11:179-182.

• Voss A, Wessel N, Hasart A, Hahnel H, Prasse G, Schirdewan A, Osterziel KJ. Analyse von Kurzzeit-Blutdruck- und Herzfrequenzvariabilit�t. Biomed.Tech.(Berl). 1998;43 Suppl:106-107.

• Strohm O, Osterziel KJ, Dietz R. Insulin-like growth factor-I and risk of breast cancer. Lancet 1998;352:489.

• Pfeufer A, Busjahn A, Vergopoulos A, Knoblauch H, Urata H, Osterziel KJ, Menz M, Wienker TF, Faulhaber HD, Steinmetz A, Schuster H, Dietz R, Luft FC. Chymase gene locus is not associated with myocardial infarction and is not linked to heart size or blood pressure. American Journal of Cardiology 1998;82:979-981.

• Osterziel KJ, Strohm O, Schuler J, Friedrich M, H�nlein D, Willenbrock R, Anker SD, Poole-Wilson PA, Ranke M, Dietz R. Randomised, double-blind, placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy. Lancet 1998;351:1233-1237.

• Malberg H, Wessel N, Hasart A, Osterziel KJ, Voss A. Duale Sequenzmethode zur Analyse der spontanen Barorezeptorensensitivit�t Biomed.Tech.(Berl). 1998;43 Suppl:532-533.

• Kerst B, Perrot A, Osterziel KJ, H�bner C, Speer A. MYF6 mutations resulting in A112S and A90D substitutions in patients with skeletal or cardiac muscle pathology. Human Mutation 1998;12:220.

• Friedrich MG, Strohm O, Osterziel KJ, Dietz R. Growth hormone therapy in dilated cardiomyopathy monitored with MRI. MAGMA. 1998;6:152-154.